Genetic investigations of sarcoidosis sub-phenotypes: Lofgren syndrome (LS) and Non-Lofgren syndrome (non-LS) – revealed that these sub-phenotypes have their own genetic architecture with a common genomic overlap located on the extended major histocompatibility complex (MHC) region.
Lofgren syndrome (LS), non-Lofgren syndrome (non-LS), and healthy controls (HC)
Further details available in High-Density Genetic Mapping Identifies New Susceptibility Variants in Sarcoidosis Phenotypes and Shows Genomic-driven Phenotypic Differences.
Rivera NV, Ronninger M, Shchetynsky K, Franke A, Nöthen MM, Müller-Quernheim J, Schreiber S, Adrianto I, Karakaya B, van Moorsel CH, Navratilova Z, Kolek V, Rybicki BA, Iannuzzi MC, Petrek M, Grutters JC, Montgomery C, Fischer A, Eklund A, Padyukov L, Grunewald J. Am J Respir Crit Care Med. 2016 May 1;193(9):1008-22. doi: 10.1164/rccm.201507-1372OC. PMID:26651848
Our latest work (as of July 2017):
“Common variants of T-cells contribute differently to phenotypic variation in sarcoidosis” in Scientific Reports is available by using the following link: